Corononavirus, stop the Oxford Astrazeneca vaccine. Garattini: “It can happen, it is not a rejection. Wait for the complete study”

Scientists and researchers are not surprised by the suspension of testing for the Oxford Astrazeneca vaccine due to a suspected serious adverse reaction in one of the volunteers being tested. “It can happen and it could also be expected, it also happens with drugs, but it is not a rejection. That is, if there is a suspicious case, we stop to understand if it is due to the product or due to situations that concern patients. Now we must avoid going into small details as much as possible and wait to see when the trial study is completed, “he tells Adnkronos Health. Silvio Garattini. Will the stop affect the entire trial? “If there is something wrong you have to check it. What should reassure is that, faced with a single suspicious case, the entire trial stops. Let’s remember that there are six vaccines tested in humans in the world, we must have confidence“.

The first studies involving 1087 people were reassuring because the participants reacted well to the administration and some reactions, such as headache or fever, were managed with paracetamol. AstraZeneca’s shutdown comes in the ongoing debate about a possible politicization of the vaccine, especially in the United States where Donald trump Press to have it before the November elections amid doubts from experts. Not least those of Anthony Fauci, the American scientist, according to whom it is unlikely that a vaccine will be ready by the end of the year. “It is unlikely that we will have a definitive answer” on the safety and efficacy of a vaccine by the end of the year, “Fauci said at an online research event.”The vaccine takes time. Please do not rush to say that we will already vaccinate at the end of the year: it is a scientifically unfounded utopia – Adnkronos Salute emphasizes Maria Rita Gismondo, director of the Laboratory of Clinical Microbiology, Virology and Bioemergencies Diagnosis of the Sacco Hospital in Milan – Unfortunately in science to say that I said it is very sad, because what is at stake is the health and the hopes of the people. But the news that AstraZeneca has temporarily stopped vaccine testing – continues Gismondo – gives credence to what some of us said, like the immunologist Alberto Mantovani: the vaccine takes a long time to be safe, no phase can be shortened. Already in the rush “of testing to get a Sars-Cov2 vaccine as soon as possible,” we have some cases to examine and investigate for side and unwanted effects: do we still want to speed up and take risks? ”. “People are not fooled,” says Gismondo. Not only. “By doing so, by running, we are playing the no vax game and we run the risk that victims will not receive other vaccines such as measles and other preventable communicable diseases.”

“The reverse of the AstraZeneca vaccine from Oxford is physiological and normal, it is not a stop but an evaluation phase, a vaccine has never been developed in a year, it takes more than three years – says 24 Mattino on Radio24 Andrea Crisanti, professor of microbiology at the University of Padua – The process is long and complex, the development of a vaccine takes approximately 5 years. Efforts are justified because it is a measure that from a cost and effectiveness point of view is the most convenient but takes time“The need for a safe and effective prophylactic compound to prevent Covid 19 by eliminating Sars Cov 2 has also imposed an effort on speed. So much so that many pharmaceutical companies have started producing potential candidates pending final results. . “Sorry to stop the experimentation, but it’s a sign that companies are working seriousness, transparency and control of data. This is the strongest argument we can have against vaccine naysayers and non-vaxes which attacked saying it would be traded without verification Here, this is the best answer that could be given to them ”, he declares. Matteo Bassetti, Infectious disease specialist at the San Martino Polyclinic Hospital in Genoa – There was a problem and the company was not ashamed to say stoppiano and let’s see what happened. We hope that they will resume soon but it is proof that the investigation is regulated and transparent ”.

There are currently five phase III vaccines: Oxford AstraZeneca, Moderna, Biontech-Fosun-Pfizer, then Sinopharm-Bibp and Sinopharm / Wuhan and Sinovac. Trials of the first are underway in the United States, Brazil and Europe. “We don’t have to worry about what happened with the Astrazeneca vaccine, the control system works and it does it very well. The company has blocked testing for non-vaxes, who say vaccines are not safe, for the peace of mind. An adverse reaction was found and the company, transparently and announcing the problem, decided to temporarily block the studies, “he explains. Antonella Viola, immunologist from the University of Padua, guest of Omnibus in La7.

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