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the vaccine research, with Pfizer, Moderna and AstraZeneca leading the way, however, the bogeyman begins to loom that the virus responsible for Covid-19 May become resistant the antidote, making it less effective or completely useless, as can happen with antibiotics.
The warning comes from David A. Kennedy and Andrew F. Read, two scientists at the Center for Infectious Disease Dynamics in the Department of Biology at Pennsylvania State University, that finding a vaccine that can end it is vitally important. to the pandemic that has been bringing the world to its knees since last February, but at the same time it is necessary to take some precautions in its development, so that it continues to be effective in time.
The coronavirus could resist the vaccine
“As we have seen with other diseases, such as pneumonia, the evolution of resistance can the make vaccines quickly ineffective“Professor Kennedy said. What worries most at this time, in addition to the possible side effects of the vaccine, is that the virus can mutate and thus become vaccine resistant. To solve this problem it is necessary to learn from “Previous challenges”, trying to design an antidote that is capable of withstanding the long term, Kennedy added.
To monitor staff virus changes, pharmaceutical companies should use samples of biological material taken, through nasal swabs, by volunteers participating in the clinical trial. In this way, it will be possible to compare them with the samples of the volunteers who were administered the placebo and evaluate if there has been a change in the virus that would indicate “The potential for resistance to evolution”.
However, the two scientists claim that the likely to develop resistance against the vaccine is an event much more rare compared to drugs. A striking example is, in fact, the antidotes used against polio, measles or smallpox, which have been the same for many years.
The production of different types of vaccines, those produced in Russia and in China use whole virus particles, inactivated or attenuated, to trigger an immune system response, while those of Pfizer me Modern, which could be available from December if they get approval from the Food and Drug Administration, means that the immune system only reacts to part of the coronavirus, the so-called protein spike.
Despite being based on different functions, the virus could become resistant to both proposalsexplains Professor Kennedy, stating that “We have seen vaccine resistance evolve against many different types of vaccines”, but nevertheless “There are also many examples for each of these where the resistance never arose“He concluded.
