a SUBSTANCE BLOCKS COVID-19 and is found in NATURE. Here is WHERE »ILMETEO.it

QUERCETIN, a compound of natural origin against CORONAVIRUSMan, or rather science, works tirelessly to provide “protection” against CORONAVIRUS which will result in the VACCINE. According to Minister of Health, Roberto Speranza, should be available
at the end of 2020 or early 2021 at the latest. But in the meantime, if the wait for the solution produced by the medical-scientific world lasts a few more months, from NATURE there is hope for a new weapon against Covid-19. An international study in which the Nanotechnology Institute of the National Research Council, Cnr-Nanotec of Cosenza, participated, suggests that QUERCETINE, a naturally occurring compound, functions as a specific Sars-CoV-2 inhibitor. In fact, the substance shows a destabilizing action on 3CLpro, one of the key proteins for the replication of the pathogen. The study, supported by the Spanish Foundation hna, was published in the International Journal of Biological Macromolecules.

The new job, led by Bruno Rizzuti of Cnr-Nanotec with a group of researchers from Zaragoza and Madrid, shows that quercetin, blocking the enzymatic activity of 3CLpro, it is “lethal” for Sars-CoV-2. In short, KILL the VIRUS. Computer simulations have shown that quercetin binds exactly to the active site of the 3CLpro protein, preventing it from performing its function properly, says Rizzuti, author of the computational part of the study, as this molecule is on par with the best antivirals available against coronaviruses, however, none of which are approved as drugs.

The quercetin a series of properties and is present in abundance for example in capers, purple onion and chicory. It is known for its antioxidant, anti-inflammatory, antiallergic, and antiproliferative properties. Its pharmacokinetic properties are also known and it is well tolerated by humans. “Since it cannot be patented, anyone can use it as a starting point for further research.”The study is based on an experimental characterization of 3CLpro, the main protease of SARS-CoV-2 “, says Olga Abian |, from the University of Zaragoza and first author of the publication: “This protein has a dimeric structure, made up of two identical subunits, each with an active site that is essential for its biological activity. In the first phase of the work, the sensitivity to various temperature and pH conditions was studied with various experimental techniques: an important result because many groups are working on 3CLpro as a possible pharmacological target, since it is strongly conserved in all types of coronavirus. For this protein, molecules that act as inhibitors have already been reported in the literature, but cannot be used as drugs due to their side effects ”.

In conclusion, new research that could support that of the vaccine. And above all, help those who cannot get vaccinated for various reasons.

QUERCETINE molecule