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Tumors, a very important and revolutionary discovery by the Veneto Institute of Molecular Medicine (VIMM) and the University of Padua. A new experimental compound blocks the tumor growth. The results obtained demonstrate, in particular, that angiogenesis, the process of formation of new blood vessels essential for tissue repair and regeneration, but also for tumor growth and metastasis development, depends on the Opa1 protein present in mitochondria.
IN DEEP
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Metabolism change to block tumor growth: research with Padua https://t.co/ZpylREpr9N
– Matteo Furlan (@ MatFur92) April 23, 2020
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Using an innovative anti-Opa medicine1 investigators managed to block the tumor growth. There are several drugs in clinical use that block the angiogenesis process and remove nutrients from the tumor preventing it from growing, but often these drugs cannot prevent the progression of the disease. Despite the proven efficacy of some medications, they cannot block tumor expansion. “We discovered, explains Luca Scorrano, scientific director of Vimm, that mitochondria rapidly change shape when angiogenesis is activated, an indication of their involvement in the process of new blood vessel formation. A bioinformatic analysis indicated that the mitochondrial protein Opa1 could being involved in these sudden changes in shape during angiogenesis. Belgian researcher Stéphanie Herkenne has verified that Opa1 activation is really essential for angiogenesis: if Opa1 is not activated, angiogenesis cannot continue. The genetic inactivation of the Opa1 gene in Blood vessel cells block the growth and metastasis of tumors in laboratory experiments, two processes that depend precisely on angiogenesis. Using an experimental compound that blocks Opa1, the researchers noted a 70-80% reduction in the growth of experimental tumors.
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