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the Pfizer vaccine for coronavirus uses mRNA to produce an immune response in the recipient’s body. An innovative and safe technology. Acknowledgment from AIFA, the Italian Medicines Agency, on the vaccine and its content.
Index:
Vaccination campaign against Covid-19
With the V-day The dances of the vaccination campaign against the Coronavirus symbolically initiate the December 27, 2020, just before the end of the year so maligned that it shocked the world with an unprecedented pandemic crisis. the Pfizer vaccine Came to Italy and the first health workers were vaccines, the “front” of the battle against the invisible enemy.
The effort to produce a vaccine in record time, the multi-million dollar investments dedicated to scientific research, were completed yesterday. with the start of administration throughout the European Union.
After the approval of theAIFA, Italian Medicines Agency, marketing of the COVID-19 vaccine has been authorized Comirnaty, developed by BioNTech and Pfizer.
As reported on the agency’s website, the Direct General Nicola Magrini denied doubts about the “alleged risks” of the vaccine, stating instead that the vaccine “has no absolute contraindications and no special precautions are required for specific subpopulations such as the elderly, immunosuppressed, or subjects with bleeding disorders and risk of bleeding. There are no contraindications even for pregnant and lactating women.
A positive note, which sheds light on the numerous conspiracy theories that have clouded the view of events, at various times during the long course of this pandemic.
For the avoidance of doubt, we report on the composition of the Pfizer vaccine, developed in collaboration with the German BioNTech, distributed by AIFA.
What is mRNA?
The novelty of the vaccine has been discussed in detail in recent months.
The focus of attention on the competitors came late in the game. Two, in particular, crossed the finish line first, Pfizer / BioNTech and Moderna. Both products developed by these two competitors take advantage of theMRNA (We talk about it in this article).
Only the popular science magazine Attention, had dedicated an interesting report to the characteristics of vaccines that exploitMRNA or messenger RNA. An innovative technology that, before the Coronavirus outbreak, it had been used in some studies to find a vaccine for certain types of cancer.
The purpose of the Pfizer vaccine is prevent coronavirus disease 2019 (COVID-19). To do this, the scientists thought of using mRNA: a molecule that contains the “instructions” for making the amino acids that make up proteins.
In particular, a strand of mRNA containing “the recipe” is used to produce the protein spike that allows the virus to enter cells. This protein in itself is harmless. However, once administered, it triggers the “alarming” immune system. By doing so, it induces the production of an immune response.
“The COVID-19 mRNA BNT162b2 vaccine (Comirnaty) is made with messenger ribonucleic acid (mRNA) molecules that contain instructions for the cells of the vaccinated person to synthesize Spike proteins. In the vaccine, the mRNA molecules are inserted into a microscopic lipid vesicle that allows the mRNA to enter the cells. Once injected, the mRNA is absorbed into the cytoplasm of the cells and initiates the synthesis of Spike proteins “(source: AIFA)
In this way, in case of real contact with the virus, the organism will be prepared because it has already known the peak protein.
Pfizer vaccine: what’s inside?
As reported by the official website ofAIFA, the Pfizer vaccine, COVID-19 BNT162b2 mRNA (Comirnaty) It will only be delivered to the population aged 16 and over.
The purpose of the vaccine is prevent coronavirus disease 2019 (COVID-19). As we have seen, it is based on mRNA.
“Contains a molecule called messenger RNA (mRNA) with instructions to make a protein present in SARS-CoV-2, the virus responsible for COVID-19.
The vaccine does not contain the virus and cannot cause the disease “(source: AIFA)
This vaccine is given as two injections in the arm 21 days apart.
The composition of the Pfizer vaccine has been made public for months and is available on the AIFA website. To complete, we report the “list of ingredients” indicated by the agency.
- Messenger RNA is enclosed in liposomes consisting of CLA-0315 ((4-hydroxybutyl) azanediyl) bis (hexane-6,1-diyl) bis (2-hexyldecanoate) and CL-0159 (2-[(polietilenglicole)-2000]-N, N-ditetradecylacetamide). ALC-0315 and ALC-0159 are synthetic lipids that help form the vesicles that carry the vaccine.
- 1,2-Distearoyl-sn-glycero-3-phosphocholine
- cholesterol
- potassium chloride
- potassium dihydrogen phosphate
- Sodium chloride
- Disodium phosphate dihydrate
- saccharose
- water for injections
