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The start of the vaccination campaign in some cities of the Germany was postponed due to some concerns about the correct storage of the vaccine Pfizer and BioNTech. The problems would be related to Cold chain necessary for the preservation of the drug in approximately one thousand doses. This was reported by the Dpa agency, cited by Reuters.
When reading the temperatures in the refrigerated containers, doubts arose about the compliance of the cold chain, say in a joint statement the administrators of some districts of the Bavaria (Coburg, Kronach, Kulmbach, Hof, Bayreuth and Wunsiedel), who asked Pfizer and BioNTech if the vaccine can still be used without problems. If not, they were assured, the batches will not be inoculated.
The Pfizer and BioNTech preparation, which, like Moderna’s, is based on the revolutionary mRna technology, i.e. messenger Rna, was stored in a -70 degree centigrade temperature.
After removing it from the refrigerated containers, the vaccine can stay between 2 and 8 degrees for up to 5 days. Health workers, after opening a container, saw that the temperature had risen to 15 degrees centigrade: above the maximum indicated by the producers.
The reefer containers used by Pfizer and BioNTech are equipped with GPS to allow manufacturing companies to check for any problems in real time.
Moderna’s vaccine, according to the company, remains stable at standard refrigeration temperatures between 2 and 8 degrees for 30 days (like those of the flu, ed); up to 30 days in domestic refrigerators and at room temperature for up to 12 hours; and up to 6 months at -20 degrees, the temperature of most drug stores and home freezers.
As Sandro Modeo indicates in an essay at Corriere, mRNA is a compound that tends to degrade rapidly due to its extremely high instability, due to the large amount of enzymes present, and therefore to the incessant swarm of chemical reactions: a trend that exposes a drug to the mRNA at risk of breaking down before reaching the cytoplasm and ribosome. Modern managed to package the molecule in nanoparticles capable of guaranteeing a different structural stability to the product, and therefore greater ease of storage, transport and preservation.
The preparation of AstraZeneca does not require any particular precautions: a normal refrigerator, at – 4 degrees Celsius, is sufficient.
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