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The clandestine “landing” of the Chinese vaccine against Covid among the eastern communities of Campania remains an unknown factor, as well as the question mark on the irrelevant percentage of infected. In Naples, where, since October 2020, only 5 cases of Coronavirus positivity have been registered out of the 5,200 Chinese registered, the hypothesis of the appropriation of the drug through the black market feared by the spokesman for the Chinese community in Naples Wu zhiqiang “Can’t be excluded” as it says Paola Paderni, director of the Confucius Institute and professor of history and institutions of China at the University “L’Orientale” in Naples. “The Chinese trust their means, many have preferred to return home because they feel safer while those who have stayed here have self-regulated, strictly respecting the rules,” explains the professor, “between the communities they use to exchange information with chats. on digital platforms. “.
In conversations, now more focused than ever on Covid remedies, there are often “homeopathic tips and herbal practices to strengthen the immune system,” he explains. Song Xiaoling, former university professor of “L’Orientale”. “I have friends who went to China to get vaccinated, paying about 10 euros, there are at least 5 types of drugs, all privately marketed,” says Song, skeptical of the idea of a clandestine vaccine in vials. “The drug for the syringes must be stored in specific refrigerators – says the 62-year-old man from Shanghai – the hypothesis of an imported vaccine could be in oral form but in this case, we do not know its effectiveness.”
Certainly, the possibility of a clandestine Chinese vaccine is in Finance’s sights. The provincial commander’s financiers have always been attentive to imported material Gabriele failla They will carry out specific checks on China’s stocks and everything that can be traced back to the transport of medicines: refrigerators, “dedicated” storage materials, plants to be used for pharmaceuticals. At the forefront in recent months with regard to the introduction of false or non-compliant sanitary material with the standards of the European community (a typical example is the seizures of masks, gloves or gels that do not meet the standards), the department of Finance aims to track any trafficking in drugs that do not meet national health criteria. Maximum attention (in full synergy with the work carried out by the police and carabinieri) in ports, airports and customs, also to verify the possible existence of vaccines or alternative medicines used in the Chinese community of Naples, based on what is happening in the homeland.
READ ALSO Covid in Naples, the Chinese immune to the virus: the mystery of the vaccine came from Beijing
CHINESE RESEARCH
Of the dozen SarsCov2 vaccines that have reached the world in an advanced stage of testing (phase 3 to verify efficacy and safety), five are Chinese. On December 8th in the ranks of WHO’s marketing candidates, the first on the list is from the Land of the Dragon – it’s Coronavac from Sinovac Biotech, a Beijing-based biopharmaceutical company. The test will be completed in two weeks. The vaccine is a complete inactivated virus: “It is the ancient technology that is also used for Salk’s polio vaccine, which is still used today – remember Franco Buonaguro, head of virology at Pascale dei Napoli – the risk is that there is a certain percentage of the virus that is not completely inactive but generally works with little inactive viral material and a large dose of viral proteins, in particular Spike ». In June, phase 1 and 2 studies in 743 volunteers found no serious adverse effects and produced an immune response. The details, released in November, show relatively modest antibody production, but phase 3 studies began in July in Brazil, then Indonesia and Turkey are underway. On October 19, Brazilian officials said it was the safest of the five they were testing.
SINOFARMA
A very similar vaccine to Coronava is the one developed by the Beijing Institute Sinopharm and China National Biotec group (Cnbg), a subsidiary of the state-owned Wuhan giant Sinopharm – they use the same inactivated virus approach. “This does not require sophisticated platforms or genetic engineering,” explains Bonaguro, “the virus is chemically inactivated (beta propriolactone) and mixed with an adjuvant (alum)”. In theory, such vaccines can produce broader antibody responses because they contain the full range of viral proteins and require normal refrigeration. «The Chinese – adds Giulio Tarro, Chief Emeritus of Cotugno – have been dedicated to the production of classic vaccines using inactivated viruses such as Salk’s polio. Another method used by Chinese companies and others (Astra Zeneca-Irmb, Reithera et al. Ed.) Uses a vector such as Sabin’s antipolytic, as has been done recently for Ebola, to induce a response to coronal proteins. This is the case of the third Chinese CanSino vaccine from Beijing, based in Tianjin, under study.
CANSINO
CanSino Biologics has developed a vaccine against an adenovirus called Ad5 in collaboration with the Institute of Biology of the Academy of Military Medical Sciences. It is in a single dose: the modified adenovirus produces the spike protein that induces the antibodies. This is the same platform as the influenza, tuberculosis, chikungunya, zika, menB, plague, and measles vaccines. The promising results of Phase 1 (safety) were published in The Lancet in May and Phase 2 (immunity) in July. In June, the Central Military Commission began administering the soldiers on an experimental basis. Since August, CanSino has started to conduct phase 3 tests in several countries: Arabia, Pakistan, Russia, Egypt, Mexico, Morocco. Thousands of people (healthcare workers, government officials) have taken this and other vaccines in China and large-scale trials are nearing completion (2-4 weeks). The strict criteria of the current certification processes in the US, Japan and Europe may not recognize them. The adverse reactions? Those with attenuated virus were mild to moderate depending on the dose. Severe events of 6% to 17% in the high dose group. Pain, fever, headache, fatigue, also classified as severe, the most common but transient and self-limited.
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