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Covid-19 patients can develop a “double damage” to the lung which is associated with higher mortality. This was revealed by a prospective observational study conducted in seven different Italian hospitals (Policlinico di Modena, Ospedale Maggiore, Niguarda and the Humanitas Clinical Institute in Milan, San Gerardo Hospital in Monza, and Gemelli Polyclinic in Rome) on 301 Covid patients. -19 people older than 18 years admitted to intensive care units and mechanical ventilation between March 9 and 22, 2020.
Higher mortality with “double damage” to the lung
The results, published in the scientific journal Lancet respiratory medicine indicated that “when the virus affects both the lung parenchyma and the coagulation or vascular system, the mortality rate at 28 days is extremely high“. The study was coordinated by Professor Marco Ranieri, Director of Anesthesia and Polyvalent Intensive Care of the S. Orsola Polyclinic, with the participation of Professor Franco Locatelli of the Bambino Gesù Hospital, president of the Higher Health Council and member of the Scientific Technical Committee. . “Identifying this phenotype – explain the researchers – important for ongoing anticoagulant and thrombolytic studies“Therefore, the findings will allow patients at risk to be identified more quickly, in order to target therapies.
Specifically, it is estimated that early diagnosis leads to a drop in mortality of up to 50%. Sars-Cov-2, reports a note issued by Ansa, can damage both components of the lung: the alveoli, which are the units of the lung that take in oxygen and release carbon dioxide, and the capillaries, the blood vessels where the exchange occurs. between carbon dioxide and oxygen. “When it damages only one component, just over 20% of patients die. The phenotype, which is the way in which the conditions manifest, of patients with ‘double damage’ is easily identifiable through the measurement of a lung function parameter (lung compliance less than 40, compared to a normal value of 100 ). and a blood chemistry parameter (D-dimer greater than 1800 with a normal value of 10)”.
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