New Delhi: About 50 percent of the Indian population is less susceptible to severe Covid-1to, and this is probably because Neanderthals and modern humans clashed with each other thousands of years ago. Or so claims a group of researchers from Japan and Germany.
According to researchers behind a study Published In P.N.A.S. Last week, about half the Indian population Inherited 75,000-character-long DNA sequences from Neanderthals that are believed to reduce the risk of serious disease caused by Covid-19.
The study, conducted by researchers at the Okinawa Institute of Science and Technology Graduate University (OIST) in Japan and the Max Planck Institute for Evolutionary Biology in Germany, sought to examine a gene variant associated with a 22 percent risk of severe covidia. 19 and ICU admissions in another study conducted in December. It found a type similar to that found in three different Neanderthal specimens.
This is not the first part of research to find a connection between Neanderthals, an ancient human species that became extinct 40,000 years ago, and covid sensitivity in modern humans.
In July last year, a Study By researchers at Max Planck Institute for Evolutionary Anthropology Found that a portion of the human genome that is at increased risk of serious disease from Covid-19 was inherited from Neanderthals 60,000 years ago. It is estimated that 30 percent of South Asians have this gene sequence.
“It’s absolutely amazing that even though Neanderthals became extinct about 40,000 years ago, their immunity still affects us today, both positively and negatively,” said Svante Pabo of OIIST. Statement Published with study.
Hugo Zeberge, one of the authors of the study, told Theranpen that about 50 percent of Indians have this DNA sequence. He added that the frequency of this gene variant is 49.5 per cent among Gujaratis and 48 per cent among Telugu people.
Also read: Neanderthals had no bruises. They were workers capable of caring for the weak
For thousands of years
Neanderthals developed in western Eurasia about five million years ago. Nevertheless, their genes have a biological influence on the physiology of modern humans, as they have merged with the human population over the last decade of thousands of years of their existence.
Neanderthals adapted to the climate outside of Africa for the hundreds of years they lived there. During this time, they adapted to potential infectious diseases.
It is believed that – the international breeding between Neanderthals and modern humans – who trace their origins to Africa – is believed to be Get in touch Each species of the novel virus, and Exchange of adaptive gene variables that have provided resistance to this virus.
For example, two gene types that reduce the susceptibility to Helicobacter pylori – infectious bacteria that cause inflammation in the stomach and some types of stomach cancer – are thought to Inherited From Neanderthals.
Above July 2020 study A gene variant in a field on chromosome 3, inherited from Neanderthals, the virus that causes SARS-CoV-2, Covid-19, increases the risk of serious illness upon infection.
Chromosomes are thread-like structures located inside the structure of cells. Humans have 23 pairs of chromosomes. Each chromosome is made up of proteins and a single molecule of deoxyribonucleic acid (DNA).
DNA contains specific instructions or genetic codes that make each one unique.
In December, a A team of researchers From the University of Edinburgh Found Jean Forms located on chromosome 12 reduce the risk that a person’s need for intensive care after infection is about 22 percent.
Study published in P.N.A.S. Last week showed that the pattern is similar to that seen in three Neanderthals – Neanderthals from Croatia, which are 20,000,000 years old, and two from southern Siberia, one 100,000 years old and the other 130,000 years old.
Chromosome 12 extends about 134 million DNA building blocks (base pairs) and represents between 4 and 4.5 percent of the total DNA in cells.
The gene variant sequences mentioned in this paper are about 75,000 base pairs.
The 75,000 base pairs for enzymes produced on viral infections activate three genes in a sequence of codes and, in turn, other enzymes that degrade the viral genome in infected cells. Simply put, three genes help the body kickstart the biological process that attacks when infected with a virus.
“It appears that the enzymes encoded by the Neanderthal variant are more efficient, making them less likely to have serious consequences of SARS-COV-2 infection.”
Also read: Neanderthal gift serving our well-wishers
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