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Jakarta, CNBC Indonesia – Lately, a new type of variant of the corona virus (SARS-CoV-2) called D614G has been widely debated. The reason is that this variant is considered very contagious.
Furthermore, this variant has reportedly also been found in major Indonesian cities such as DKI Jakarta, Tangerang, Yogyakarta, Bandung, and Surabaya. There is no need to get confused if you read the variant word that means type.
In simple terms, a variant can be defined as a type of virus that is still in the same group but has several differences. Like humans.
They are both human but can have different eye colors. Some are brown, blue, and black indicating a variant, as well as the corona virus that is to blame for the current Covid-19 pandemic.
As additional information, the name of the D614G variant is based on the arrangement of a chemical molecule called an amino acid that forms the external structure of the virus called a protein. Spike.
The existence of mutations or genetic changes can lead to differences in the arrangement of the amino acids that make up the structure. Spike which will eventually make new variants appear.
Several studies have shown that this D614G variant is the dominant variant of the corona virus that spreads globally. However, the latest research conducted by Korber et al and published in international scientific journals Cell last August 20 showed amazing results.
In this study, Korber showed evidence that the D614G variant began to be replaced by another variant called the G614. This variant reportedly first appeared in Europe on February 22 and has now become the dominant form.
 Issue: Korber et al., 2020, Cell 182, 812–827 August 20, 2020 Posted by Elsevier Inc |
Initially, the most dominant mutation was the D614G variant. But over time the G614 variant appeared and began to circulate together. However, it is now experiencing a significant increase in the frequency of circulation in many populations.
The problem is that this variant turns out to be easier to infect its host than the old D614G variant.
“We also found that G614 was associated with elevated viral nucleic acid in the upper respiratory tract in human patients. viral load highest and most infectious in the multiple pseudotype test, “the report wrote.
Based on available follow-up data, the G614 variant spreads faster than the D614G, making it more contagious, and this hypothesis is also consistent with in vitro and in vivo testing.
“Interestingly, we found no evidence of an effect of G614 on disease severity. This means that this was not significantly associated with hospitalization status. However, an association between the G614 variant and higher mortality rates was reported in comparisons of death rates between countries, despite analysis. This is difficult given the availability of evidence and treatment varies by country, “the report said.
In general, this new type is more contagious. However, more research is still needed to determine if it results in increased severity and mortality in patients. So what are the real implications of the discovery of this new variant of the corona virus?
“If the G614 variant is indeed more contagious than the D614 form, it may require higher antibody levels to obtain protection against the virus from a vaccine or other antibody therapeutic than D614.” the report said.
CNBC INDONESIA INVESTIGATION TEAM
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