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Scientists around the world are developing vaccines and medications for the coronavirus. At this time it is known that there is no definitive cure method for COVID-19 patients. When undergoing treatment, patients receive medication or therapy based on the condition or symptoms they experience.
As a race against time, many studies have been done to examine drugs and vaccines to avoid the Corona virus. He noted that there are several vaccine and drug candidates who have entered the clinical trial stage. In addition to medications and vaccines, various therapies are also performed as a Corona healing method.
The following is quoted from Reuters.
1. Mesmosate of camostat
The drug, which is licensed in Japan and South Korea, was originally used to treat patients with chronic kidney disease. During the Corona pandemic, initial laboratory tests were carried out to see if this drug was able to prevent COVID-19 from infecting the cells of the body.
In early April, researchers from Aarhus, Denmark conducted a two-stage trial of the drug camostat mesylate in approximately 180 patients with COVID-19. The University of Tokyo also carried out mesylate tests on the camostat and related medications, such as the mesamate respiramostat. The results are expected to be detected in December 2020.
2. IFX-1
Initially, IFX-1 was developed to block the inflammation mechanism and block inflammation in pneumonia patients. Scientists in the Netherlands began to examine the benefits of oni medications in COVID-19 patients with severe lung conditions. Initial test results are expected to complete in late October 2020.
3. Aspirin, clopidogrel, rivaroxaban, atorvastatin, and omerazol.
Some British medicines used for heart disease have also been studied as a treatment for the Corona virus. Heart medications were used in this study because some reports saw a link between viral infections and heart disease. Trials with these drugs have been conducted in 3,000 patients in the UK. The completion target is expected to be completed by March 2021.
4. BCG tuberculosis vaccine
Australian and Dutch researchers are quickly moving to large-scale trials to determine whether a vaccine used for decades to prevent tuberculosis, tuberculosis, or BCG (Bacillus Calmette-Guerin) can be used as a coronavirus vaccine to protect medical workers.
The BCCG vaccine is used to see if it will boost the body’s immunity, including healthcare workers, the elderly, people with a history of respiratory disease, including patients who are positive for COVID-19.
5. INO-4800
Inovio Pharmaceuticals and Coalition For Epidemic Preparedness Innovations are developing the INO-4800 vaccine. The company is also collaborating with the Beijing Advaccine Biotechnology Company.
As of March 3, the INO-4800 has started the preclinical testing phase and 3,000 doses have been prepared for America, China, and South Korea. Human trials will be conducted in April 2020, results may be known in September 2020. Inovio aims for production of 1 million vaccines by the end of 2020.
6. Ad5-nCoV
Chinese biopharmaceutical company CanSino Biologics began clinical trials for the COVID-19 Ad5-nCoV vaccine using RNA or genetic information from the coronavirus. The Phase 1 trial was conducted in Wuhan, China with 108 subjects last March to assess safety and the resulting immune response.
On April 12, a phase 2 trial was conducted with 500 randomized participants to test a placebo dose. Completion of Phase 1 is said to be completed in late December 2020 and Phase 2 in January 2021.
7. ChAdOx1
The University of Oxford in the UK developed a vaccine called ChAdOx1 that was tested in phases 1 and 2. The clinical trial is aimed at 1,112 people aged 18-55 divided into 4 groups receiving different doses. This test is expected to be completed in May 2021.
8. New inactivated coronavirus pneumonia vaccine
The Beijing Biological Products Institute and the Wuhan Biological Products Institute develop the Corona vaccine against an attenuated virus. Vaccine trials have entered stage one. The vaccine was tested at the Wuzhi County Disease Control and Prevention Center and at the Wuzhi People’s Hospital.
The number of samples involving hundreds of people divided into dozens of groups receiving different doses. The goal of the study is to end on November 10, 2021.
9. Antibody / Serology Experiments
Some countries have analyzed blood samples to show whether a person is exposed to the virus, with or without symptoms. Serology-based test to measure the levels of antibodies that form during infection.
Through this experiment, it is hoped that medical personnel will be able to identify which antibodies are appropriate to respond to the vaccine to be administered to the patient. This test was first performed on patients with COVID-19 in China. Serological tests for the Corona virus are now known as rapid tests.
10. Blood plasma therapy
Blood plasma recovered from COVID-19 patients is currently being studied as a therapy for sick patients. The patient’s cured blood plasma is expected to help fight the virus.
Blood plasma therapy has been tested in several countries to treat patients with Corona, especially in critical conditions. Treatment with blood plasma is done by injecting blood plasma containing antibodies from patients cured with Corona into patients with COVID-19 who are still struggling with this disease.
Controlled trials are underway in China, Europe, the United States, India and Indonesia to gather evidence of greater benefits for blood plasma therapy.
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