[ad_1]
Jakarta, CNN Indonesia – Chinese researcher Li Lanjuan and other researchers from Zhejiang University found corona virus SARS-Cov-2 causes disease Covid-19 can mutate Up to 30 variants.
Up to 19 of the 30 variants of this mutation are new types. In other words, 60 percent of the mutation findings are the result of new mutations. Some of the changes are found so rarely that the researchers did not consider such mutations to exist.
Based on laboratory evidence, Li’s research also found that certain mutations of the SARS-Cov-2 virus can create a more deadly type of virus than other types.
“SARS-Cov-2 has obtained mutations that can substantially change its pathogenicity (the body’s ability to cause disease),” said Li.
The rate of this coronavirus mutation is around one mutation per month. As of Monday (4/20) there are an estimated 10,000 strains sequenced by researchers from around the world. So 4,300 mutations have been recorded based on the China National Bioinformation Center.
Furthermore, it evaluated that different strains could have a different effect on Covid-19 in the world. According to Li, world researchers still underestimate the ability of this virus mutation.
Conclusions Li and the team carried out after conducting a series of studies related to the SARS-CoV-2 coronavirus mutation in a small group of patients that had not been previously reported.
Li uses an ultra-deep sequencing method called very sophisticated. Each genome is read more than 100 times. In this way, researchers can see the changes that are likely to be lost from conventional approaches.
According to Professor Zhang Xuegong, head of the bioinformatics division at Tsinghua University, this technique can be very effective in tracking virus mutations. Although he said the approach was very expensive and time consuming.
Li and team’s findings are published. medrxiv.org Entitled, “Patient-derived Mutations Affect the Pathogenicity of SARS-Cov-2”. However, this study has not been evaluated by other researchers.
According to scientific publications written by Li and other researchers, they analyzed virus strains isolated from 11 randomly selected Covid-19 patients from Hangzhou City. This city was chosen because there were 1,264 Covid-19 positive patients.
The samples taken in this test are classified as few. Other studies related to virus mutations generally involve hundreds of thousands of virus samples.
They then tested how efficiently the virus strain could infect and kill cells. The result, mutations that are considered fatal in these patients have also been found in the majority of patients living on the European continent.
 Illustration Researchers say there are new variants of the coronavirus mutation once a month. (Doc. CNN.com) |
Although the variant of the coronavirus mutation that has a milder infection is the dominant variety found in Washington, in the United States, as reported South China Morning Post.
Although based on separate studies, virus variants in New York were mentioned to be similar to viruses that exist in many European countries. Therefore, it is estimated that the virus in the city was imported from Europe.
Li also emphasized that mutations that weaken the coronavirus do not mean that the risk of infection is no longer fatal to everyone.
Because, according to their research, two patients between the ages of 30 and 50 who contracted the virus were not too virulent and suffered from shortness of breath. Both survived, but older patients needed care in the intensive care unit (intensive care unit / ICU).
“This study produces an unexpected picture, shown by a handful of patients we tested, that there are differences from virus strains that are still largely underestimated,” Li said.
More virulent virus mutations are said to kill cells that become infected more quickly. Because it multiplied 270 times more than a weaker virus mutation.
The results of this study are believed to help researchers better understand how a strain varies by geographic area.
Therefore, Li hopes that this study can help determine the development of a vaccine for this virus and its mutation variants and the best way to combat the SARS-Cov-2 virus. Sputnik News.
“The development of drugs and vaccines, while seemingly urgent, must take into account the impact of the accumulation of these mutations,” Li concluded.
According to a report by the local news agency, Li was the first scientist to propose the blockade in Wuhan. The government immediately followed the advice and immediately closed overnight. Therefore, some residents were forced to separate from their families during the shutdown because they were unable to return to their homes when they were out of town.
Previously, researchers in the United Kingdom and Germany identified three types of SARS-CoV-2 coronavirus mutations that cause Covid-19 pain that spread around the world. These three mutations of the coronavirus are marked A, B, and C.
Variant A is the original variant that first infected humans as in Wuhan. But surprisingly, this variant is not a type of virus that infects most city residents.
Their analysis showed that the version of Mutation A was seen in the United States who had previously lived in Wuhan. Additionally, large amounts of type A viruses are found in patients in the United States and Australia.
The main type of Wuhan virus is a descendant of variant B, and this virus predominantly affects patients throughout East Asia. However, the variant did not extend beyond other regions without further mutations.
Variant C was identified as an important European type and was found in early patients from France, Italy, Sweden and England. This variant was not found in the Mainland Chinese study sample, but was found in Singapore, Hong Kong, and South Korea. (din / ex)
[Gambas:Video CNN]
[ad_2]
