NEW DELHI: Bharat Biotech on Wednesday signed a licensing agreement with the Washington University School of Medicine in St Louis, USA, for a new intranasal single dose “chimpanzee adenovirus” vaccine for Covid-19.
As Covid cases continue to show an increase around the world, several nations are working on vaccines that are generally injected orally or in the arm. However, some groups, including Biotech, are also using another approach: developing nasal vaccines to attack the virus more quickly.
Here is everything you need to know:
What is a nasal vaccine?
* Nasally, the dose of the vaccine is administered through the nose, rather than orally or through the arm.
* As the goal is to deliver a dose that goes directly to the respiratory tract, the vaccine is injected through a specific nasal spray or by aerosol administration.
How does it work?
* Since the virus normally enters your body through the nose, the nasal vaccine causes your immune system to produce proteins in your blood and in your nose that help you fight the virus.
* A doctor will spray the vaccine into your nostrils with a small syringe that does not have a needle.
* It usually takes about two weeks to start working.
* Given the potency and rapid spread of the coronavirus, some say it makes sense to develop airway vaccines, as well as more standard injections.
How is the nasal vaccine different?
* Many microbes, including the coronavirus, enter the body through the mucosa (moist, soft tissues that line the nose, mouth, lungs, and digestive tract), triggering a unique immune response from cells and molecules there .
* Intramuscular vaccines generally fail to elicit this mucosal response and must instead rely on mobilized immune cells from other parts of the body that come to the site of infection.
How effective is it?
* An effective nasal dose not only protects against Covid-19, but also prevents the spread of the disease by offering another type of immunity that occurs mainly in the cells that line the nose and throat.
* The nasal vaccine targets immune cells present in the mucosal membrane and tissue, providing both systemic and mucosal immunity in other sites such as the lungs and intestines. Thus, a nasal vaccine may be better able to inoculate crowds against the deadly infection and prevent even the development of mild symptoms.
* According to Bharat Biotech, this intranasal vaccine candidate has shown unprecedented levels of protection in mouse studies; the technology and data have recently been published in the prestigious scientific journal ‘Cell’ and in an editorial in ‘Nature’.
Benefits of the nasal vaccine
* An intranasal vaccine will not only be easy to administer but will reduce the use of medical consumables such as needles, syringes, etc., which will significantly affect the overall cost of a vaccination campaign.
* Director of the Center for Biological Therapeutics and Professor of Radiation Oncology at the University of Washington School of Medicine and Precision Virology. easier administration.
Countries that develop nasal vaccine
* Various research groups, including teams in India, the United States, Canada and the Netherlands, are working on nasal vaccines against coronavirus.
* On September 11, China also approved its first nasal spray vaccine to combat the novel coronavirus for trials. China’s only nasal spray vaccine is expected to begin phase I clinical trials in November, and is recruiting 100 volunteers.
(With contributions from the agency)
As Covid cases continue to show an increase around the world, several nations are working on vaccines that are generally injected orally or in the arm. However, some groups, including Biotech, are also using another approach: developing nasal vaccines to attack the virus more quickly.
Here is everything you need to know:
What is a nasal vaccine?
* Nasally, the dose of the vaccine is administered through the nose, rather than orally or through the arm.
* As the goal is to deliver a dose that goes directly to the respiratory tract, the vaccine is injected through a specific nasal spray or by aerosol administration.
How does it work?
* Since the virus normally enters your body through the nose, the nasal vaccine causes your immune system to produce proteins in your blood and in your nose that help you fight the virus.
* A doctor will spray the vaccine into your nostrils with a small syringe that does not have a needle.
* It usually takes about two weeks to start working.
* Given the potency and rapid spread of the coronavirus, some say it makes sense to develop airway vaccines, as well as more standard injections.
How is the nasal vaccine different?
* Many microbes, including the coronavirus, enter the body through the mucosa (moist, soft tissues that line the nose, mouth, lungs, and digestive tract), triggering a unique immune response from cells and molecules there .
* Intramuscular vaccines generally fail to elicit this mucosal response and must instead rely on mobilized immune cells from other parts of the body that come to the site of infection.
How effective is it?
* An effective nasal dose not only protects against Covid-19, but also prevents the spread of the disease by offering another type of immunity that occurs mainly in the cells that line the nose and throat.
* The nasal vaccine targets immune cells present in the mucosal membrane and tissue, providing both systemic and mucosal immunity in other sites such as the lungs and intestines. Thus, a nasal vaccine may be better able to inoculate crowds against the deadly infection and prevent even the development of mild symptoms.
* According to Bharat Biotech, this intranasal vaccine candidate has shown unprecedented levels of protection in mouse studies; the technology and data have recently been published in the prestigious scientific journal ‘Cell’ and in an editorial in ‘Nature’.
Benefits of the nasal vaccine
* An intranasal vaccine will not only be easy to administer but will reduce the use of medical consumables such as needles, syringes, etc., which will significantly affect the overall cost of a vaccination campaign.
* Director of the Center for Biological Therapeutics and Professor of Radiation Oncology at the University of Washington School of Medicine and Precision Virology. easier administration.
Countries that develop nasal vaccine
* Various research groups, including teams in India, the United States, Canada and the Netherlands, are working on nasal vaccines against coronavirus.
* On September 11, China also approved its first nasal spray vaccine to combat the novel coronavirus for trials. China’s only nasal spray vaccine is expected to begin phase I clinical trials in November, and is recruiting 100 volunteers.
(With contributions from the agency)
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