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Moderna provided more information on clinical trials and preparations for the production of the Covid-19 candidate vaccine. Based on this, the preparation, which works on the principle of a messenger RNA, provides protection for a long time.
In a letter to the editor of the New England Journal of Medicine (NEJM), he reported preliminary data from NIH-led phase I studies of the mRNA-1273 vaccine to support the persistence of the vaccine’s efficacy.
“Although natural defense mechanisms against SARS-CoV-2 infection in humans do not yet exist, these results indicate that mRNA-1273 is capable of providing sustained humoral immunity despite an expected slight decrease in neutralizing antibody titer. and union “, summary. the results in the article.
As Moderna reports from the research results, vaccination is effective in establishing protection, regardless of age. However, several elements are still being studied, such as the long-term effects of the vaccine, not only its efficacy, but also possible safety problems. A 13-month follow-up study was started to assess immunogenicity. According to a phase 3 study measuring efficacy, your vaccine is 94.5 percent effective.
Moderna expects that between 100 and 125 million doses of the vaccine will be available worldwide in the first quarter of 2021 (85 to 100 million will be available in the United States and 15 to 25 million outside). This amount already includes a portion of the 500 million -1 billion doses that the company plans to produce globally in 2021.
The company is developing an mRNA vaccine, the principle of operation of such preparations is to trick cells because instead of a complete virus, only a viral protein is produced with them. Therefore, the defensive reaction develops much more quickly. Another characteristic of these vaccines is that they induce a stronger immune response than conventional vaccines. The advantage of mRNA vaccines is that they are easy to produce in large quantities because the process is shorter than with conventional vaccines, a few months instead of 1-2 years.
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