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Manchester City can get one step closer to their third title in four seasons by beating third-placed Leicester at the King Power Stadium.
Pep Guardiola’s men are 14 points ahead of second-placed Manchester United and 15 points ahead of Leicester.
Chasing an unprecedented quadruple, City will also have their Champions League quarter-final first leg against Borussia Dortmund on Tuesday in the back of their minds.
Leicester thrashed City 5-2 in September and their hopes for another famous win could rest on former Manchester City forward Kelechi Iheanacho, voted Premier League Player of the Month in March after scoring seven goals in his last four games across all competitions.
In the last game of the day, Liverpool can take advantage of Chelsea’s stumble when traveling to Arsenal.
Jurgen Klopp’s side can move within two points of Chelsea if they score a second consecutive league win for the first time since January.