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The Foxes have won their last two in the league and will attempt to reach the FA Cup semi-finals for the first time since 1982.
Here’s everything you need to know about the match:
The game will begin at 5 pm at the King Power Stadium.
The game is live BBC One with coverage from 4:30 pm. The match can also be streamed online via the BBC Sport website and BBC iPlayer.
Ricardo Pereira will be missing after a hamstring injury in the comfortable win over Sheffield United. Harvey Barnes, James Justin (both knee), James Maddison (hip), Wes Morgan (back) and Cengiz Under (thigh) are all out, but Dennis Praet has returned from his hamstring injury.
Marcus Rashford, Edinson Cavani and Anthony Martial are ready to be evaluated before the start of the game. Phil Jones remains out.
Leicester City: Schmeichel, Fofana, Evans, Soyuncu, Castagne, Ndidi, Tielemans, Thomas, Perez, Iheanacho, Vardy
Manchester United: Henderson, Wan-Bissaka, Lindelof, Maguire, Telles, Fred, Matic, James, Fernandes, Pogba, Greenwood
These two teams played a heartbreaking 2-2 draw in the Premier League equivalent to this match, but the injuries keep coming for the Foxes so I think United will win. 2-1 Manchester United.