Coronavirus: USC Scientists Detect Probable Sequence of COVID-19 Symptoms


LOS ANGELES (KABC) – USC researchers have found the probable sequence in which COVID-19 symptoms first appear.

The findings show that infected people are more likely to experience fever, then cough and muscle aches, followed by nausea, and / or vomiting, and diarrhea.

Knowing the sequencing of COVID-19 symptoms can help patients seek rapid care or sooner rather than later decide to isolate themselves, according to scientists at the USC Michelson Center for Convergent Bioscience. The information may also help physicians rule out other diseases, or help physicians plan how to treat patients, and perhaps intervene in the disease earlier.

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The study, which was published Thursday in the journal Frontiers in Public Health, was led by doctoral candidates Joseph Larsen and scientists Peter Kuhn and James Hicks at the Convergent Science Institute at USC Michelson Center in Cancer.

“This sequence is especially important to know when we have overlapping cycles of diseases such as the flu that coincide with COVID-19 infections,” said Kuhn, a USC professor of medicine, biomedical engineering, and space and mechanical engineering. ” Physicians can determine what steps to take to care for the patient, and they can prevent the patient’s condition from deteriorating. ‘ ‘

Fever and cough are often associated with a variety of respiratory diseases, including flu, Middle Eastern respiratory syndrome and Severe Acute Respiratory Syndrome. However, the timing and symptoms in the upper and lower gastrointestinal tract separate COVID-19.

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“Given that there are now better approaches to COVID-19 treatments, patients can identify hospital admission time sooner,” Larsen said.
To determine chronology of coronavirus symptom, the authors analyzed more than 55,000 confirmed cases of coronavirus in China collected from February 16 to February 24 by the World Health Organization. They are also studying a dataset of nearly 1,100 cases collected from December 11 through Jan. 29. By the China Medical Treatment Expert Group through the National Health Commission of China.

In addition, to compare the sequence of symptoms of COVID-19 with influenza, the researchers examined data from 2,470 cases in North America, Europe and the Southern Hemisphere, which were reported to health authorities from 1994 to 1998.

“The order of the symptoms are important,” Larsen said. Knowing that each disease progresses differently means that doctors can identify sooner if someone is likely to have COVID-19, or another disease, which can help them make better treatment decisions. ”

City News Service contributed to this report.

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