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Researchers from the German Primate Center (DPZ) in Göttingen have managed to find starting points for the development of vaccines and therapy for the SARS 2 coronavirus. Infection biologists identified the so-called spike protein as the key to the host cell, which also it has an unusual activation sequence. The furin cell enzyme cleaves this sequence, which is a prerequisite for infection of lung cells. Stefan Pöhlmann, head of the infection biology department at DPZ, concludes that the spread of SARS coronavirus 2 in the lungs can be prevented by inhibiting the enzyme furin. Therefore, virus variants whose activation sequence for furin has been removed could be used as the basis for live vaccines, said study lead author Markus Hoffmann. If the spike protein is not divided, the virus could spread less in the body. Symptoms of the disease would not be triggered, but the immune system could still produce antibodies.
