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If Manchester United win their games in hand, they will be second in the table, just two points behind league leaders Liverpool.
First, the Red Devils will meet rivals Leeds United later in the evening. Who will come out on top?
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Coach Ole Gunnar Solskjaer can make three or four changes to the team that started in the midweek competition against Sheffield United.
In goal, David De Gea should replace Dean Henderson again.
Wan-Bissaka, Maguire and Lindelof could retain their starting positions at the baseline, but Luke Shaw could replace Alex Telles to start in the left-back role.
When it comes to central midfield, Fred and Mctominay should take the places of Matic and Pogba again.
In the attacking third, players like Rashford, Fernandes and Greenwood could start behind lone striker Martial.
Here’s the strongest possible 4-2-3-1 XI from Man Utd against Leeds:
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